Тимол-В для пчел — инструкция по применению

Тимол-В для пчел — инструкция по применению

Thymol

Identification

A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)

Type Small Molecule Groups Approved Structure

Structure for Thymol (DB02513)

  • FEMA NO. 3066
  • NSC-11215
  • NSC-47821
  • NSC-49142

Pharmacology

Learn about our commercial Contraindications & Blackbox Warnings data.

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Learn about our commercial Adverse Effects data.

Interactions

  • Approved
  • Vet approved
  • Nutraceutical
  • Illicit
  • Withdrawn
  • Investigational
  • Experimental
  • All Drugs

Extended description of the mechanism of action and particular properties of each drug interaction.

A severity rating for each drug interaction, from minor to major.

A rating for the strength of the evidence supporting each drug interaction.

An effect category for each drug interaction. Know how this interaction affects the subject drug.

Products

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

Mixture Products

Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
Advanced Antiseptic Thymol (.064 mL/100L) + Eucalyptol (.042 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L) Mouthwash Oral Wakfern Food Corporation 2010-11-24 Not applicable US
Advanced Antiseptic Thymol (.064 kg/100L) + Eucalyptol (.092 kg/100L) + Levomenthol (.042 kg/100L) + Methyl salicylate (.060 kg/100L) Mouthwash Oral Demoulas Supermarkets, Inc. 2010-07-22 Not applicable US
Advanced Antiseptic Citrus Thymol (.042 mL/100L) + Eucalyptol (.092 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L) Mouthwash Oral H.E.B. 2010-10-15 Not applicable US
Advanced Antiseptic Citrus Thymol (.042 mL/100L) + Eucalyptol (.092 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L) Mouthwash Oral Drug Mart 1991-06-15 Not applicable US
Advanced Citrus Thymol (.064 kg/100L) + Eucalyptol (.092 kg/100L) + Levomenthol (.042 kg/100L) + Methyl salicylate (.060 kg/100L) Mouthwash Oral Walmart Stores 2010-07-22 Not applicable US
Advanced Citrus Antiseptic Thymol (.064 mL/100L) + Eucalyptol (.092 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L) Mouthwash Oral Publix Supermarkets, Inc. 2001-05-03 Not applicable US
Amber Mouth Rinse Thymol (0.64 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Levomenthol (0.42 mg/1mL) + Methyl salicylate (0.6 mg/1mL) Liquid Oral Filo America 2013-07-30 Not applicable US
Amber Mouth Wash — Liq Thymol (0.064 %) + Eucalyptol (0.092 %) + Levomenthol (0.042 %) Liquid Dental Perrigo International 1996-10-09 1999-08-06 Canada
Amber Mouthwash — Liq Thymol (0.064 %) + Eucalyptol (0.092 %) + Levomenthol (0.042 %) Liquid Dental Perrigo International 1996-06-30 1999-08-06 Canada
Anitseptic Mouth Rinse Thymol (0.64 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Levomenthol (0.42 mg/1mL) + Methyl salicylate (0.60 mg/1mL) Mouthwash Oral Pharmacy Value Alliance LLC 2003-08-19 Not applicable US

Unapproved/Other Products

Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
Antiseptic Rinse Thymol (.064 kg/100L) + Eucalyptol (.092 kg/100L) + Levomenthol (.042 kg/100L) + Methyl salicylate (.060 kg/100L) Mouthwash Oral Meijer 2006-08-08 Not applicable US

Categories

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antifungal Agents
  • Benzene Derivatives
  • Monoterpenes
  • Terpenes

Chemical Identifiers

References

Clinical Trials

Phase Status Purpose Conditions Count
4 Not Yet Recruiting Prevention Caries / Periodontal Diseases 1
Not Available Recruiting Treatment Periodontitis / Type 2 Diabetes Mellitus 1

Pharmacoeconomics

Dosage Forms

Form Route Strength
Oil Topical 0.7 g/50g
Liquid Dental
Rinse Oral
Mouthwash Oral
Mouthwash Buccal
Liquid Topical .5 mL/1L
Spray Topical .06 mL/120mL
Lotion Topical
Spray Topical
Powder Topical
Ointment Topical
Oil Topical 0.5 g/50g
Soap Topical 0.0004 1/1kg
Soap Topical 0.0004 kg/1kg
Spray Topical 0.0005 kg/1kg
Cloth Topical 0.0005 kg/1kg
Oil Topical 1.5 g/50g
Mouthwash Buccal; Oral
Gel Transdermal
Patch Transdermal
Liquid Topical 0.3 g/100mL
Gel Topical
Oil Topical 1.7 g/50g
Mouthwash Dental; Oral
Jelly Nasal
Liquid Topical
Soap Topical 0.0024 kg/1kg
Lozenge Oral
Liquid Oral
Stick Topical
Plaster Topical
Patch Cutaneous; Topical; Transdermal
Mouthwash Dental
Spray Oral 0.05 g/100mL
Liquid Respiratory (inhalation)

Prices Not Available Patents Not Available

Properties

State Solid Experimental Properties

Property Value Source
melting point (°C) 51.5 °C PhysProp
boiling point (°C) 232.5 °C PhysProp
water solubility 900 mg/L (at 20 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP 3.30 HANSCH,C ET AL. (1995)
pKa 10.6 (at 20 °C) SERJEANT,EP & DEMPSEY,B (1979)

Predicted Properties

Property Value Source
Water Solubility 0.643 mg/mL ALOGPS
logP 3.16 ALOGPS
logP 3.43 ChemAxon
logS -2.4 ALOGPS
pKa (Strongest Acidic) 10.59 ChemAxon
pKa (Strongest Basic) -5.2 ChemAxon
Physiological Charge ChemAxon
Hydrogen Acceptor Count 1 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 20.23 Å 2 ChemAxon
Rotatable Bond Count 1 ChemAxon
Refractivity 47.27 m 3 ·mol -1 ChemAxon
Polarizability 17.84 Å 3 ChemAxon
Number of Rings 1 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter No ChemAxon
Veber’s Rule Yes ChemAxon
MDDR-like Rule No ChemAxon

Predicted ADMET Features

Property Value Probability
Human Intestinal Absorption + 0.9955
Blood Brain Barrier + 0.9381
Caco-2 permeable + 0.9153
P-glycoprotein substrate Non-substrate 0.722
P-glycoprotein inhibitor I Non-inhibitor 0.9343
P-glycoprotein inhibitor II Non-inhibitor 0.9883
Renal organic cation transporter Non-inhibitor 0.9036
CYP450 2C9 substrate Non-substrate 0.7352
CYP450 2D6 substrate Substrate 0.7838
CYP450 3A4 substrate Non-substrate 0.5667
CYP450 1A2 substrate Inhibitor 0.9107
CYP450 2C9 inhibitor Non-inhibitor 0.907
CYP450 2D6 inhibitor Non-inhibitor 0.9368
CYP450 2C19 inhibitor Non-inhibitor 0.9026
CYP450 3A4 inhibitor Non-inhibitor 0.9196
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.7429
Ames test Non AMES toxic 0.9282
Carcinogenicity Non-carcinogens 0.7195
Biodegradation Not ready biodegradable 0.7808
Rat acute toxicity 2.2996 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.8987
hERG inhibition (predictor II) Non-inhibitor 0.9087

Spectra

Mass Spec (NIST) Not Available Spectra

Spectrum Spectrum Type Splash Key
Predicted GC-MS Spectrum — GC-MS Predicted GC-MS Not Available
GC-MS Spectrum — EI-B GC-MS splash10-000i-0900000000-333dc57384e65e3b4cfa
GC-MS Spectrum — EI-B GC-MS splash10-000i-1900000000-3679938a5ea114a30e48
GC-MS Spectrum — EI-B GC-MS splash10-000i-3900000000-8ce5865e48dad7250d5e
GC-MS Spectrum — EI-B GC-MS splash10-0udi-0109030000-5562c203cb318f30321b
GC-MS Spectrum — GC-EI-TOF GC-MS splash10-0a4i-2492200000-85342d698be72263a95f
Mass Spectrum (Electron Ionization) MS splash10-000i-4900000000-73edaa628c1f5f2e1bd9
MS/MS Spectrum — Quattro_QQQ 10V, Positive (Annotated) LC-MS/MS splash10-01p9-9700000000-e1a28495617d7b014e5c
MS/MS Spectrum — Quattro_QQQ 25V, Positive (Annotated) LC-MS/MS splash10-014i-9300000000-baeee6cdcafaadeebdec
MS/MS Spectrum — Quattro_QQQ 40V, Positive (Annotated) LC-MS/MS splash10-015c-9100000000-e1efa41eaf818832448a
MS/MS Spectrum — EI-B (SHIMADZU LKB-9000B) , Positive LC-MS/MS splash10-000i-0900000000-333dc57384e65e3b4cfa
MS/MS Spectrum — EI-B (HITACHI RMU-6L) , Positive LC-MS/MS splash10-000i-1900000000-3679938a5ea114a30e48
MS/MS Spectrum — EI-B (HITACHI M-80B) , Positive LC-MS/MS splash10-000i-3900000000-f72f603d97f0f7081b8d
Predicted MS/MS Spectrum — 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum — 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum — 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum — 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum — 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum — 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
1H NMR Spectrum 1D NMR Not Applicable
13C NMR Spectrum 1D NMR Not Applicable
[1H,13C] 2D NMR Spectrum 2D NMR Not Applicable

There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Contact us to learn more about these and other features.

Drug created on June 13, 2005 07:24 / Updated on June 12, 2020 10:52

Thymol

Identification

Code # 5211 S

CAS [89-83-8]

Family MONOTERPENE

Sub family MONOTERPENE

Formula C10H14O

MW 150.22

Link PCIDB

Synonym 2-Isopropyl-5-methylphenol

Smiles CC(C)C1=C(O)C=C(C)C=C1 CC(C)C1=C(O)C=C(C)C=C1

Specification

Thymol analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Purity (GC) ≥99% (This product is delivered with GC chromatogram)

Bibliography

    • Monograph
    • 289
    • EP / Rhatany root
    • 2015
    • Monograph
    • 1888
    • EP / Rhatany tincture
    • 2015
    • Monograph
    • 406
    • EP / Peppermint leaf
    • 2011
    • Monograph
    • 405
    • EP / Peppermint oil
    • 2012
    • Monograph
    • 865
    • EP / Thyme
    • 2014
    • Monograph
    • 1374
    • EP / Thyme oil thymol type
    • 2012
    • Monograph
    • 1880
    • EP / Oregano
    • 2011
    • Monograph
    • 1349
    • EP / Myrrh
    • 2008
    • Monograph
    • 1877
    • EP / Myrrh tincture
    • 2008
    • Monograph
    • 2543
    • EP / Turmeric Rhizome
    • 2013
    • Monograph
    • 1441
    • EP / Turmeric Javanese
    • 2015
    • Monograph
    • 2475
    • EP / Poria
    • 2012
    • Monograph
    • 2023
    • EP / Allium sativum (homoeopathic)
    • 2014
    • Monograph
    • 1862
    • EP / Colophony
    • 2008
    • Monograph
    • 2432
    • EP / Acanthopanax bark
    • 2012

Safety

Hazard statement :
H302 Harmful if swallowed — H314 Causes severe skin burns and eye damage — H411 Toxic to aquatic life with long lasting effects

Precautionary statement :
P260 Do not breathe dust/fume/gas/mist/vapours/spray. — P273 Avoid release to the environment. — P280 Wear protective gloves/protective clothing/eye protection/face protection. — P302+P352 IF ON SKIN: Wash with plenty of soap and water. — P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. — P332+P313 If skin irritation occurs: Get medical advice/ attention. — P337+P313 If eye irritation persists: Get medical advice/attention.

Порошок Тимол-В против заразных заболеваний пчел

Препарат выпускает российское предприятие УНИФАРМ. Активный компонент — тимол. Терапевтическая форма— порошок для орального применения.

Как работает препарат

Тимол-В представляет собой белый порошок, расфасованный во флакончики либо пакеты по 3 г.

Стоимость в сентябре 2019 г. — 108 р.

Применение

Тимол применяют для борьбы с нозематозом, европейским и американским гнильцами, грибковыми заболеваниями, клещевыми инвазиями. Обрабатывают дважды — во время весеннего облета пчел и осенью, во время наращивания семей.

Различают следующие способы применения тимола:

  1. Подкормка сахарным сиропом. Тимол растворяют горячей водой, затем добавляют в небольшое количество сиропа. Путем ступенчатого смешивания приготавливают рабочий раствор, представляющий собой 25 л 50% сахарного сиропа, в котором равномерно распределены 3г тимола. Лекарством заправляют вечером потолочные кормушки либо разливают в опустевшие соты по 0,1 л на одну рамку с пчелами. Обработку повторяют 4 раза с интервалом в 3 дня.
  2. Подкормка ветеринарным канди. Тимол равномерно распределяют в 10 кг медово-сахарного теста. Раскладывают по 40г на рамку. Для профилактики проводят одно терапевтическое скармливание. Если возникла необходимость в лечении, обработку повторяют 3 раза с недельным интервалом.

Одна упаковка тимола рассчитана на 250 рамок. Хранят Тимол 2 года при температуре от 2 до 25 °С.

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